In the proposed research we intend to use a controlled cortical impact (CCI) model of TBI and PTE in mice and investigate behavioural, electrophysiological, histological/morphological and molecular aspects of brain function following TBI with or without MI treatment. Our previous studies provide strong support to believe, that the proposed research will provide further evidence on antiepileptogenic properties of MI and this will be a strong basis for further translational research that could lead to the development of new antiepiletogenic and antiepileptic medicine.

Principal investigator: Eka Lepsveridze