Institute of Chemical Biology
Institute of Chemical Biology is a teaching and research institution, participating in the undergraduate and one-step certified physician programme of the School of Natural Sciences and Medicine, has a graduate programme in Molecular Sciences (Molecular Biosciences, Biopharmacy, and food science) and doctoral programmes in biochemistry and molecular biology.
The Institute is currently developing the following research programmes:
- The biologically active compounds and cell regulation - The programme is addressing the topical issue in the modern biomedical sciences and includes both fundamental and practical aspects. Targeted management of biological processes can be done by means of biologically active substances; therefore, these compounds are widely used in biotechnology, microbiology, pharmaceutical and food industry. Programme aims to excrete biologically active substances – with plant or animal origin, to identify their behavioral mechanisms, impact of the activity on cell regulatory systems and determining the behavior of these compounds by developing a test-cell system. The programme will study the significance of a variety of regulatory macromolecules in the initiation of endocrine and inflammatory diseases and will study possibilities of correction of these disorders using plant origin polyphenolic compounds spread in Georgia. Cytotoxic and pharmacological potential of the biologically active substances can be determined using cell culture.
- Study of cell and molecular fundamentals of memory - The programme addresses one manifestation of synaptic plasticity – memory and studies the visual imprinting model in chickens. The work focuses on changes in the gene expression in the memory formation processes. It also examines epigenetic changes in the processes of memory recognition formation and storage, micro-RNA range changes in the memory recognition formation processes, and protein spectrum changes on different stages of the memory recognition formation process. The data obtained in this model will be used in the second stage of the establishment of general mechanisms of memory storage and the development of mental disease treatment strategies.
- Study of the cellular and molecular foundation of epilepsy and epileptogenesis and identifying prevention methods of epileptogenesis - The programme studies the abnormal functional activity of the central nervous system, such as epilepsy. Study focuses on Post-traumatic and kainite-caused epilepsy forms. Study of the Institute in molecular biology is focused on the following researches: changes of genetic expression in the process of epileptogenesis with the use of microarea technology and effects of chronic treatment with inositols in this process; also, changes in the process of epileptogenesis in micro-RNM spectrum and effects of chronic treatment by inositols;post-translation modifications of histons, that determine epigenetic changes as well as inositole effects; changes in methylation status of those genes, which are differently expressed based on the results of the micro area experiments and assessment of inositol influence on the processes; changes in albumen spectrum during the process of epileptogenesis and after inositol treatment; Work of the institute will be based on the the following study in the field of the cellular biology: changes in ultra-structure of neuron cells during different functional states and research on in vitro electro physiological methods in case of normal or pathological state models.
With the use of atomic force microscope, study will determine three dimensional structure, displacement, arrangement density and mechanical features (viscoelasticity) of the dendritic rough surface of hypocampus live neurons during different functional states. Different methods will be used for triggering epileptic discharges and study of the influence of pharmacological substances (for example inositols) on them. Study concentrates not only on the foundation of cellular and molecular epileptogenesis but also on the ways of its prevention.
Insitute has an integrative approach, which unites molecular biological, electrophysiological and morphological methods and provides an opportunity to generate qualitatively important results.
publications
2008
- Solomonia R., Apkhazava D., Nozadze M., Jackson A.P., McCabe B.J., Horn G. “Different Forms of MARCKS Protein Are Involved in Memory Formation in the Learning Process of Imprinting”. Exp Brain Res. 188 (2008): 323–330
- Zhvania M.G., Bolqvadze T, Solomonia R.O., Kuchiashvili N, Japaridze N.J. “Effect of Acoustic Stimulation on GABAergic Neurons in Limbic Structures of Krushinskii-Molodkina Rats”. Bull Exp Biol Med. 145 (2008): 398-400.
2009
- Zhuravliova E. Barbakadze T., Zaalishvili E, Koshoridze N., Chipashvili M., Mikeladze D Social isolation stress in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Experimental Brain Research. 205 (2009) 377–383
- Kvaratskhelia E., Maisuradze E., Dabrundashvili NG, Natsvlishvili N, Zhuravliova E., Mikeladze DG. N-Methyl-D-Aspartate and sigma -Ligands Change the Production of Interleukins 8 and 10 in Lymphocytes through Modulation of the NMDA Glutamate Receptor. Neuroimmunomodulation, 2009;16:201-207
- Zhuravliova E., T. Barbakadze T., Narmania N, Sepashvili M, Mikeladze D.G. Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in Neuronal Cells. Neurochemical Research, 2009, 34:1076–1082
2010
2011
- Kharlamov EA., Lepsveridze E., Meparishvili M., Solomonia RO., Lu B., Miller ER., Kelly KM., Mtchedlishvili Z. “Alterations of GABA(A) and Glutamate Receptor Subunits and Heat Shock Protein in Rat Hippocampus Following Traumatic Brain Injury and in Posttraumatic Epilepsy”. Epilepsy Res. 95 (2011): 20-34
- Solomonia RO., Kunelauri N., Mikautadze E., Apkhazava D., McCabe BJ., Horn G. “Mitochondrial Proteins, Learning and Memory: Biochemical Specialization of a Memory System”. Neuroscience 194 (2011): 112-123
- Shanshiashvili L, Narmania N, Barbakadze T, Zhuravliova E, Natsvlishvili N, Ramsden J, Mikeladze DG. S-nitrosylation decreases the adsorption of H-Ras in lipid bilayer and changes intrinsic catalytic activity. Cell Biochemistry and Biophysics. 59(3):191-9, 2011.
- Solomonia R., Mikautadze E., Nozadze M., Kuchiashvili N., Lepsveridze E., Kiguradze T. “Myo-Inositol Treatment Prevents Biochemical Changes Triggered by Kainate-Induced Status Epilepticus”. Neuroscience Letters 468 (2010): 277-281
- Nozadze M., Mikautadze E., Lepsveridze E., Mikeladze E., Kuchiashvili N., Kiguradze T., Kikvidze M., & Solomonia R. “Anticonvulsant Activities of myo-Inositol and scyllo-Inositol on Pentylenetetrazol Induced Seizures”. Seizure: European Journal of Epilepsy 20 (2011): 173-176
- Cho WJ, Lee JS, Zhang L, Ren G, Shin L, Manke CW, Potoff J, Kotaria N, Zhvania MG, Jena BP. Membrane-directed molecular assembly of the neuronal SNARE complex. J. Cell Mol Med. 15, 1 13-17, 2011.
2012
- Shanshiashvili LV, Dabrundashvili N, Natsvlishvili N, Kvaratskhelia E, Zhuravliova E, Barbakadze T, Koriauli S, Maisuradze E, Topuria T, Mikeladze DG. mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes. Molecular Immunology. 51(3-4): 310-315, 2012.
- Azmaiparashvili E, Berishvili E, Kakabadze Z, Pilishvili O, Mikautadze E, Solomonia R, Jangavadze M, Kordzaia D. (2012) Ductular reaction at the early terms of common bile duct ligation in the rats. Acta Biol Hung, 63,321-332
- Zhuravliova E, Barbakadze T, Jojua N, Zaalishvili E, Shanshiashvili L, Natsvlishvili N, Kalandadze I, Narmania N, Chogovadze I, Mikeladze D. Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism. Cellular and Molecular Neurobiology. 32:1311–1321, 2012
- Shanshiashvili LV, Kalandadze IV, Ramsden JJ, Mikeladze DG. Adhesive Properties and Inflammatory Potential of Citrullinated Myelin Basic Protein Peptide 45-89. Neurochemcal Research. 37, 1959-1966, 2012.
- Bátor J, Varga J, Berta G, Barbakadze T, Mikeladze D, Ramsden J, Szeberényi J. Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein. Cellular and Molecular Biology Letters. 17(3):323-32, 2012.
- Japaridze NJ, Okuneva VG, Qsovreli MG, Surmava AG, Lordkipanidze TG, Kiladze MT, Zhvania MG. Hypokinetic stress and neuronal porosome complex in the rat brain: the electron microscopic study. Micron, 2012, 43, 9, 948-954, 2012.
- V.G. Okuneva, N.J. Japaridze, N.T. Kotaria, and M.G. Zhvania. Neuronal Porosome in the Rat and Cat Brain. Cell and Tissue Biology. 2012, 6, 1, 69-72, 2012.
- Okuneva VG, Dzhaparidze ND, Kotaria NT, Zhvaniia MG. Neuronal porosome in the rat and cat brain. Tsitologiia. 254, 4, 324-328, 2012.
- Zhvania MG, Chilachava LR, Japaridze NJ, Gelazonia LK, Lordkipanidze TG. Immediate and persisting effect of toluene chronic exposure on hippocampal cell loss in adolescent and adult rats. Brain Research Bulletins, 87, 2, 187-192, 2012.
- M.G. Zhvania, N.J. Japaridze, M. Ksovreli, M. Kiladze, V. Okuneva, A. Surmava, T. Lordkipanidze, N. Kotaria. Effect of chronic hypokinetic stress on the structure of axo-dendritic synapses in the central nucleus of the amygdala of the rat: an electron microscopic investigation. Journal of Biological Physics and Chemistry, 12, 4, 148-152, 2012.
- T. Z. Bikashvili, L. R., Chilachava, L. K. Gelazonia, N. J. Japaridze, M. G. Zhvania, T. G. Lordkipanidze and Okuneva V. G., Effectof Chronic Inhalation of Toluene on Behavior of Rats of Various Age Groups in MultiBranched Maze. Bulletin of Experimental Biology and Medicine, 152, 5, 587-589 (Translated in USA in English), 2012.
2013
- Barbakadze T, Natsvlishvili N, Mikeladze D. Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin avß3 receptor in undifferentiated and differentiated PC-12 cells. Cell Biochemistry and Function, 2013
- Mzia G. Zhvania, Nadezhda J, Japaridze, Lela R. Chilachava, Lia K. Gelazonia, Tamar Z. Bikashvili, Manana G. Dashniani, Maia Burjanadze. Immediate and persisting effect of toluene chronic exposure on recognition memory, locomotor activity, behavior in multibranch maze and hippocampal structure. in Book: Toluene: Chemical Properties, Applications and Toxicology. Nova Science Publishers, Inc., Marco C. Palminteri USA. p. 53-92, 2013.
- Kotaria N, Kiladze M, Zhvania MG, Japaridze NJ, Bikashvili T, Solomonia RO, Zhvania M, Bolkvadze T. The protective effect of Myo-inositol on hippocampal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus, Cell Mol Neurobiol. 33(5):659-71, 2013.
- Lordkipanidze T, Bikashvili T, Japaridze N,, Zhvania M.The Effect of kainic acid on hippocampal dendritic spine motility at the early and late stages of development, Micron, 49, 28-32, 2013.
- Solomonia, R., Gogichaishvili, N.,Nozadze M.,Lepsveridze E., Dzneladze D., Kiguradze T. Myo-Inositol Treatment and GABA-A Receptor Subunit Change After Kainate-Induced Status Epilepticus. Cellular and Molecular Neurobiology, 33, 119-127, 2013
- Solomonia RO, Meparishvili M, Mikautadze E, Kunelauri N, Apkhazava D, McCabe BJ. (2013) AMPA receptor phosphorylation and recognition memory: learning-related, time-dependent changes in the chick brain following filial imprinting. Experimental Brain Research. 226,297-308
- Kotaria N, Kiladze M, Zhvania MG, Japaridze NJ, Bikashvili T, Solomonia RO, Bolkvadze T. (2013) The protective effect of Myo-Inositol on hippocampal cell loss and structural alterations in neurons and synapses triggered by kainic acid-induced status epilepticus. Cellular and Molecular Neurobiology, 33,:659-71
- Solomonia, R., Lepsveridze, E., Kiguradze, T. Nozadze, M. (2013) Inositols and Epilepsy In “Inositol: Synthesis, Functions and Clinical Implications” Eds: H.Rocha and M.Cardoso. NOVA Publishers,pp.105-128
2014
- Jojua N., Sharikadze N., Zhuravliova E., Zaalishvili E., Mikeladze D.G. Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. Nutritional Neuroscience, 2014
- Babuadze G, Alvar J, Argaw D, de Koning HP, Iosava M, Kekelidze M, Tsertsvadze N, Tsereteli D, Chakhunashvili G, Mamatsashvili T, Beria N, Kalandadze I, Ejov M, Imnadze P. Epidemiology of visceral leishmaniasis in Georgia. PLoS Negl Trop Dis. 2014 Mar 6;8(3):e2725
- Mzia Zhvania, Tamar Lordkipanidze, Maia Kiladze, Nadezhda Japaridze, Nato Kotaria, Tamar Bikashvili – The Effect of kainic acid on the rat brain: histological, Electron-microscopic and Two-photon microscopic study. in Book: Kanic Acid: Neurotoxic Properties, Biological Sources and Clinical Applications. Nova Science Publishers, Inc.USA, (Book ID: 4939) (accepted for publication), 2014.
- Mzia Zhvania, Nadezhda Japaridze, Mariam Ksovreli – Effect of different forms of hypokinezia on the ultrastructure of limbic, nbeocortical and extrapyramidal structures of the rat brain. Proceedings of Physics. Springer International Publishing Switzerland (Accepted for publication), 2014.
- Mzia G. Zhvania, Nadezhda J. Japaridze, Mariam G, Qsovreli, Vera G. Okuneva, Arkadi G. Surmava, Tamar G. Lordkipanidze. The Neuronal Porosome Complex in Mammalian Brain: A Study Using Electron Microscopy. Chapter: NanoCell Biology: Multimodal Imaging in Biology and Medicine. Editors: Jena B.P., Taatjes D.J. Pan Stanford Publishing Pte. Ltd. In: Neuronal Porosome Complex, (2014 April).
- Gegelashvili G and Bjerrum OJ High-affinity glutamate transporters in chronic pain: an emerging therapeutic target. Journal of Neurochemistry, 2014
- Toft-Kehler AK, Skytt DM, Poulsen KA, Brændstrup CT, Gegelashvili G, Waagepetersen H, Kolko M. Limited energy supply in Müller cells alters glutamate uptake. Neurochemical Research, 2014, 39(5):941.
- Molecular Mechanisms of memory in imprinting, Solomonia RO, McCabe BJ.NeurosciBiobehav Rev. 2014 Oct 2: S0149-7634(14)00240-1.
- Molecular phylogeny of hantaviruses harbored by insectivorous bats in Cote d’Ivoire and Vietnam, Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L,Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song JW, Yanagihara R.Viruses. 2014 Apr 29;6(5):1897-910.
- Meparishvili M, Nozadze M, Margvelani G, McCabe BJ, Solomonia RO (2015) A Proteomic Study of Memory after imprinting in the domestic chick. Front Behav Neurosci. 2015 Nov 26;9:319.
- Solomonia RO, McCabe BJ. “Molecular mechanisms of memory in imprintingNeurosci Biobehav Rev. 2015 Mar;50:56-69.
2015
- Caballero-Garrido E, Pena-Philippides JC, Lordkipanidze T, Bragin D, Yang Y, Erhardt EB, Roitbak T. (2015) In vivo inhibition of miR-155 promotes recovery after experimental mouse stroke. J Neurosci. 2015 Sep 9;35(36):12446-64.
- Kelly KM, Miller ER, Lepsveridze E, Kharlamov EA, Mchedlishvili Z. (2015) Posttraumatic seizures abd epilepsy in adult rats after controlled cortical impact. Epilepsy Res. 2015 Nov;117:104-16.
- Schmalbach B, Lepsveridze E, Djogo N, Papashvili G, Kuang F, Leshchyns’ka I, Sytnyk V, Nikonenko AG, Dityatev A, Jakovcevski I, Schachner M. (2015) Age-dependent loss of parvalbumin-expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene. J Neurochem. 2015 Nov;135(4):830-44.
- Zhvania MG, Japaridze NJ, Qsovreli MG, Okuneva VG, Surmava AG, Lordkipanidze TG.(2015) Electron microscopic morphometry of isolated rat brain porosome complex Neurosci Res.Nov;100:17-20.
- Zhvania MG, Ksovreli M, Japaridze NJ, Lordkipanidze TG. Ultrastructural changes to rat hippocampus in pentylenetetrazol and kainic acid-induced status epilepticus: A study using electron microscopy Micron. 2015 Jul;74:22-9.
- Datukishvili N, Kutateladze T, Gabriadze I, Bitskinashvili K, Vishnepolsky B. New multiplex PCR methods for rapid screening of genetically modified organisms in foods. Frontiers in Microbiology. 2015 Jul 24;6:757.
- Gabriadze I., Kutateladze T., Vishnepolsky B., Karseladze M., Zaalishvili T., Datukishvili N., Muskhelishvili G. (2015) Polymerase Chain Reaction Based Assays for Specific Detection of Barley. Bulletin of the Georgian National Academy of Sciences, v. 9 (1), pp. 145-150
- Natsvlishvili N., Goguadze N., Zhuravliova E., Mikeladze D. Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria., BMC Biochemistry, 2015, 16:11
- Koriauli S, Natsvlishvili N, Barbakadze T, Mikeladze D.Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons. Biological Research. 2015 Oct 9;48(1):55.
- Jojua N, Sharikadze N, Zhuravliova E, Zaalishvili E, Mikeladze DG., Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. Nutrition Neuroscience. 2015 Jul;18(5):225-31.
- Datukishvili N, Kutateladze T, Gabriadze I, Bitskinashvili K, Vishnepolsky B. New multiplex PCR methods for rapid screening of genetically modified organisms in foods. Frontiers in Microbiology. 2015 Jul 24;6:757.
- Koriauli S, Natsvlishvili N, Barbakadze T, Mikeladze D., Knockdown of interleukin-10 induces the redistribution of sigma1-receptor and increases the glutamate-dependent NADPH-oxidase activity in mouse brain neurons. Biological Research. 2015 Oct 9;48(1):55.
- Nozadze M, Zhgenti E, Meparishvili M, Tsverava L, Kiguradze T, Chanturia G, Babuadze G, Kekelidze M, Bakanidze L, Shutkova T, Imnadze P, Francesconi SC, Obiso R and Solomonia R (2015) Comparative proteomic studies of Yersinia pestis strains isolated from natural foci in the Republic of Georgia. Front. Public Health 3:239.
- Meparishvili M, Nozadze M, Margvelani G, McCabe BJ, Solomonia RO (2015) A Proteomic Study of Memory after imprinting in the domestic chick. Front Behav Neurosci. 2015 Nov 26;9:319.
2016
- Tsverava L., Lordkipanidze T., Lepsveridze E., Nozadze M. Kikvidze M. Solomonia R (2016) Myoinositol Attenuates the Cell Loss and Biochemical Changes Induced by Kainic Acid Status Epilepticus,” BioMed Research International, vol. 2016, Article ID 2794096, 14 pages, 2016.
- Babuadze G, Farlow J, de Koning HP, Carrillo E, Chakhunashvili G, Murskvaladze M, Kekelidze M, Karseladze I, Kokaia N, Kalandadze I, Tsereteli D, Markhvashvili I, Sidamonidze K, Chanturia G, Adeishvili E, Imnadze P. (2016) Seroepidemiology and molecular diversity of Leishmaniadonovani complex in Georgia.Parasit Vectors. 13;9(1):279.
- Pena-Philippides JC, Caballero-Garrido E, Lordkipanidze T, Roitbak T.(2016), In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response.J Neuroinflammation.13 (1):287.
- Elene O. Tsitsilashvili, Lali V. Shanshiashvili, David G. Mikeladze. Macrophages – cells with broad potential. JBPC, Vol.16, 4, 2016
- Nino Sharikadze, Natia Jojua, Maia Sepashvili, Elene Zhuravliova and David G Mikeladze. Mitochondrial Target of Nobiletin’s Action, Natural Product Communications, 2016, 11(12), 1835-1839
2017
- Tamar Barbakadze, Galina Goloshvili, Nana Narmania, Elene Zhuravliova, David Mikeladze. “Subcellular distribution of S-nitrosylated H-Ras in differentiated and undifferentiated PC12 cells during hypoxia“ – Cell Journal (Yakhteh)
- Lali Shanshiashvili, Elene Tsitsilashvili, Nino Dabrundashvili, Irine Kalandadze and David Mikeladze. Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. Biological Research 2017, 50:4
- Bai Y, Urushadze L, Osikowicz L, McKee C, Kuzmin I, Kandaurov A, Babuadze G, Natradze I, Imnadze P, Kosoy M. Molecular Survey of Bacterial Zoonotic Agents in Bats from the Country of Georgia (Caucasus).PLoS One. 2017 Jan 27;12(1):e0171175.
- Urushadze L, Bai Y, Osikowicz L, McKee C, Sidamonidze K, Putkaradze D, Imnadze P, Kandaurov A, Kuzmin I, Kosoy M. Prevalence, diversity, and host associations of Bartonella strains in bats from Georgia (Caucasus).PLoS Negl Trop Dis. 2017 Apr 11;11(4):e0005428.
- Margvelani G, Meparishvili M, Tevdoradze E, McCabe BJ, Solomonia RMitochondrial fusion and fission proteins and the recognition memory of imprinting in domestic chicks.Neuroreport. 2017 Nov 17. N9
- Bikashvili, T., Lordkipanidze, T., Gogichaishvili, N., Pochkhidze N. Effect of Arsenic Exposure on Behavior of Rats of Various Age Groups. Georgian Medical News; 2017; Mar; (264):119-126.
- Zhvania M.G. & Pochkidze N. (2017) Nuronal Porosome Complex: Secretory Machinery at the Nerve Terminal. Discoveries, 5(3): e77
- Shanshiashvili L, Tsitsilashvili E, Dabrundashvili N, Kalandadze I, Mikeladze D. Metabotropic glutamate receptor 5 may be involved in macrophage plasticity. Biol Res. 2017 Feb 14;50(1):4
- Stupar P, Chomicki W, Maillard C, Mikeladze D, Kalauzi A, Radotić K, Dietler G, Kasas S., Mitochondrial activity detected by cantilever based sensor. Mech. Sci., 8, 23-28, 2017
- Barbakadze T, Goloshvili G, Narmania N, Zhuravliova E, Mikeladze D. Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia..Cell J. 2017 19(3):443-451.
- Maurice T1, Goguadze N, Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia. Adv Exp Med Biol. 2017;964:213-233.
- Maurice T1, Goguadze N, Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases. Handb Exp Pharmacol. 2017;244:81-108.
- Datukishvili, N., Gabriadze, I., Kutateladze, T., Bitskinashvili, K., Vishnepolsky, B. Multiplex approach for detection of genetically modified foods. Proceedings of 19th International Conference on Food Processing and technology. Paris, France, 23 – 25 October, 2017, Journal of food processing and technology, 2017, v. 8:9, p. 38
2018
- Goguadze N, Zhuravliova E, Morin D, Mikeladze D, Maurice T. Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress. Neurotoxicity Research. 2017 Nov 10.
- Alipourfard I, Bakhtiyari S, Datukishvili N, Haghani K, Di Renzo L, De Miranda RC, Cioccoloni G, Basiratyan Yazdi P, Mikeladze D. Saccharomyces cerevisiae, key role of MIG1 gene in metabolic switching: putative fermentation/oxidation. J Biol Regul Homeost Agents. 2018 May-Jun;32(3):649-654.
- Bitskinashvili K, Gabriadze I, Kutateladze T Vishnepolsky B, Mikeladze D,Datukishvili N Effects of thermal-acid treatment on degradation and amplification of wheat and maize DNA. Journal of Food and Nutrition Research .Vol. 57, 2018, No. 3, pp. 242–251
- E. Tsitsilashvili, L. Shanshiashvili and D. Mikeladze. Some new aspects of metabotropic glutamate receptors. Journal of Biological Physics and Chemistry 18 (2018).
- Zhgenti E, Hu P, Chanturia G, Tsereteli D, Kekelidze M, Chubinidze S, Zangaladze E, Imnadze P, Andersen G, Torok T. (2018), Investigation of Yersinia pestis and Yersinia pseudotuberculosis strains from Georgia and neighboring countries in the Caucasus by high-density SNP microarray. Arch Microbiol. 2018200(9):1345-1355.
- Adamou M, Antoniou G, Greasidou E, Lagani V, Charonyktakis P, Tsamardinos I, Doyle M. (2018) Toward Automatic Risk Assessment to Support Suicide Prevention. Crisis, 26:1-8
- Khuchua Z, Glukhov AI, Strauss AW, Javadov S. (2018) Elucidating the Beneficial Role of PPAR Agonists in Cardiac Diseases. Int J Mol Sci.;19(11)
- Margvelani G, Meparishvili M, Tevdoradze E, McCabe BJ, Solomonia R.(2108) Mitochondrial fusion and fission proteins and the recognition memory of imprinting in domestic chicks.
- Margvelani G, Meparishvili M, Kiguradze T, McCabe BJ, Solomonia R. (2018) Micro-RNAs, their target proteins, predispositions and the memory of filial imprinting.Sci Rep. 8(1):17444
2019
- Sigma-1 Receptor Agonists Induce Oxidative Stress in Mitochondria and Enhance Complex I Activity in Physiological Condition but Protect Against Pathological Oxidative Stress. Neurotoxicity Research 2019; 35(1), 1-18
- TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes Mediators of Inflammation Volume 2019, 3560819
- Effects of a Gut Microbiome Toxin, p-Cresol, on the Contents of the NMDA2B Receptor Subunit in the Nucl. Accumbens of Rats Neurophysiology, Vol. 51, No. 2, 2019, 72-76
- Influence of Heat Processing on DNA Degradation and PCR-Based Detection of Wild-Type and Transgenic Maize Journal of Food Quality Volume 2019, Article ID 5657640, 11
- Sodium nitroprusside induces H-Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells. Cell Biochemistry and Function. 2019 37(7),545-552.
- Inhibition of mitochondrial cytochrome c oxidase by metabolized Nobiletin in yeast. J Biol Regul Homeost Agents. 2019 33(4):1097-1103
- MIG1 glucose repression in metabolic processes of Saccharomyces cerevisiae: Genetics to metabolic engineering, 2019 Avicenna Journal of Medical Biotechnology 11(3), pp. 215-220
- Myelin basic protein charge isomers change macrophage polarization. Journal of Inflammation Research 12, pp. 25-33, 2019
- Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O 2 Consumption and ROS Release.Can K, Menzfeld C, Rinne L, Rehling P, Kügler S, Golubiani G, Dudek J, Müller M.Front Physiol. 2019 Apr 30;10:479.
- The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids.Seneviratne AK, Xu M, Henao JJA, Fajardo VA, Hao Z, Voisin V, Xu GW, Hurren R, Kim S, MacLean N, Wang X, Gronda M, Jeyaraju D, Jitkova Y, Ketela T, Mullokandov M, Sharon D, Thomas G, Chouinard-Watkins R, Hawley JR, Schafer C, Yau HL, Khuchua Z, Aman A, Al-Awar R, Gross A, Claypool SM, Bazinet RP, Lupien M, Chan S, De Carvalho DD, Minden MD, Bader GD, Stark KD, LeBlanc P, Schimmer AD.Cell Stem Cell. 2019 Apr 4;24(4):621-636.e16.
- Effect of propionic acid on the morphology of the amygdala in adolescent male rats and their behavior.Lobzhanidze G, Lordkipanidze T, Zhvania M, Japaridze N, MacFabe DF, Pochkidze N, Gasimov E, Rzaev F.Micron. 2019 Oct;125:102732.
- Tsverava L., Kandashvili M., Margvelani G., Lortkipanidze T., Gamkrelidze G., Lepsveridze E., Kokaia M. Solomonia R. (2019) Long-Term Effects of Myoinositol on Behavioural Seizures and Biochemical Changes Evoked by Kainic Acid Induced Epileptogenesis. BioMed Research International, Volume 2019, Article ID 4518160
- Gamkrelidze GN, Nanobashvili ZI, Bilanishvili IG, Lordkipanidze T, Kandashvili M, Kokaia M, Solomonia RO. Concentration and time-dependent effects of myo-inositol on evoked epileptic afterdischarge in the hippocampus in vivo. Neuroreport. 2019 Nov 6;30(16):1129-1134
- Dashniani, Manana G.; Chighladze, Mariam R.; Solomonia, Revaz O.; Burjanadze, Maia A.; Kandashvili, Manana Chkhikvishvili, Nino C.; Beselia, Gela V.; Kruashvili, Lali B. Memantine treatment prevents okadaic acid-induced neurotoxicity at the systemic and molecular levels. NeuroReport: December 10, 2019
- O. Rcheulishvili, L. Tsverava, A. Rcheulishvili, M. Gurielidze, R. Solomonia, N. Metreveli, N. Jojua, H-Y Holman (2019) Heavy metals specific proteomic responses of a highly resistant arthrobacter globiformis 151B. Annals of Agrarian Sciences, 17,2, 218-230
2020
- Gut neurotoxin p-cresol induces differential expression of GLUN2B and GLUN2A subunits of the NMDA receptor in the hippocampus and nucleus accumbens in healthy and audiogenic seizure-prone rats.Tevzadze G, Zhuravliova E, Barbakadze T, Shanshiashvili L, Dzneladze D, Nanobashvili Z, Lordkipanidze T, Mikeladze D. AIMS Neurosci. 2020 Mar 10;7(1):30-42.
- The key role of Akt protein kinase in metabolic-inflammatory pathways cross-talk: TNF-α down-regulation and improving of insulin resistance in HepG2 cell line. Alipourfard I, Bakhtiyari S, Gheysarzadeh A, Di Renzo L, De Lorenzo A, Mikeladze D, Khamoushi A.Curr Mol Med. 2020 Apr 26.
- Chitadze L, Margvelani G, Meparishvili M, Tsverava L, Mikautadze E, Kikvidze M, Lagani V, McCabe BJ, Solomonia R.(2020)Chicken cognin interactome and the memory of filial imprinting. Neuroreport, 31(5):399-405
- Dashniani MG, Chighladze MR, Solomonia RO, Burjanadze MA, Kandashvili M, Chkhikvishvili NC, Beselia GV, Kruashvili LB.. (2020) Memantine treatment prevents okadaic acid induced neurotoxicity at the systemic and molecular levels. Neuroreport 31(4):281-286.
- Dashniani MG, Burjanadze MA, Chkhikvishvili NC, Solomonia RO, Kandashvili M, Naneishvili TL, Beselia GV, Kruashvili LB, Chighladze MR (2020) Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons. Experimental Brain Research, 238:2385–2397
- Adebayo OL, Dewenter I, Rinne L, Golubiani G, Solomonia R, Müller M. (2020) Intensified mitochondrial hydrogen peroxide release occurs in all brain regions, affects male as well as female Rett mice, and constitutes a life-long burden. Arch Biochem Biophys. 2020 Nov 5:108666.
- Lomidze N, Zhvania MG, Tizabi Y, Japaridze N, Pochkhidze N, Rzayev F, Gasimov E. (2020) Age-related behavioral and ultrastructural changes in the rat amygdala. Dev Neurobiol. 2020 Oct 23
- Zhvania M, Gogokhia N, Tizabi Y, Japaridze N, Pochkidze N, Lomidze N, Rzayev F, Gasimov E. (2020) Behavioral and neuroanatomical effects on exposure to White noise in rats. Neurosci Lett., 728:134898.
- Lobzhanidze G, Japaridze N, Lordkipanidze T, Rzayev F, MacFabe D, Zhvania M.(2020) Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism. Int J Dev Neurosci. 80(2):139-156.
- Gogokhia N, Japaridze N, Tizabi Y, Pataraya L, Zhvania MG. Gender differences in anxiety response to high intensity white noise in rats. Neurosci Lett. 2020 Dec 2:135543.
- Pochkhidze N, Gogokhia N, Japaridze N, Lazrishvili I, Bikashvili T, Zhvania MG. (2020) Electron Microscopy Demonstrating Noise Exposure Alters Synaptic Vesicle Size in the Inferior Colliculus of Cat. Noise Health
Staff
- David Mikeladze – Head of the Institute of Chemical Biology, Professor
- Revaz Solomonia – Head of the Institute of Chemical Biology, Professor
- Mzia Zhvania – Professor
- Ekaterine Lepsveridze – Professor
- Giorgi (Gogi) Gegelashvili – Professor
- Tamar Lordkipanidze – Associate Professor
- Maia Nozadze – Associate Professor
- Lali Shanshiashvili – Associate Professor
- Nino Natsvlishvili – Associate Professor
- Elene Zhuravljova – Associate Professor
- Tamar Barbakadze – Associate Professor
- Marine Kikvidze – Associate Professor
- Nana Narmania – Researcher
- Maya Sepashvili – Researcher
- Nino Sharikadze – Researcher
- Maya Mefarishvili– Researcher
Contacts
Davit Mikeladze, Director, Full Professor
2 22 17 03; 577 421 170
davit_mikeladze@iliauni.edu.ge
Revaz Solomonia, Director, Full Professor
2 22 17 03; 599 197 665
revaz_solomonia@iliauni.edu.ge
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